Cover Image

SCIENTIFIC BASIS OF a New Hypothesis: Is the Cavitation Phenomenon the Mechanism for Formation of Plaques in Coronary Arteries? Protocol of a New Study.

Thach Nguyen


In current literature, there is no confirmed mechanism for the formation and growth of atherosclerotic plaques. In reference to each individual person, the entire arterial tree is exposed to atherogenic effects of systemic risk factors and yet only a few arteries develop plaques. These plaques are observed in the coronary arteries in which they are clustered in the proximal segment of the left anterior descending artery (LAD), left circumflex (LCX), and the proximal and segments of the right coronary artery (RCA). Why is there such a pattern of spatial distribution? As seen in fluid dynamics and industrial hydraulics, the damage on the inside surface of pipes is proved to be caused by cavitation or collapse of air bubbles, a natural phenomenon that could also be similarly seen in a pattern of lightness and darkness. Could the cavitation or the ruptures of the bubbles be the mechanism of formation

Full Text:



Kolodgie FD, Virmani R, Burke AP, Farb A, Weber DK, Kutys R, Finn AV, Gold HK. Pathologic assessment of the vulnerable human coronary plaque. Heart. 2004;90:1385-1391

Laminar Flow. Encyclopedia Britanica. Retrieved from

Lee RT, Libby P. The unstable atheroma. Arteriosclerosis, thrombosis, and vascular biology. 1997;17:1859-1867

Lee SY, Mintz GS, Kim SY, Hong YJ, Kim SW, Okabe T, Pichard AD, Satler LF, Kent KM, Suddath WO, Waksman R, Weissman NJ. Attenuated plaque detected by intravascular ultrasound: Clinical, angiographic, and morphologic features and post-percutaneous coronary intervention complications in patients with acute coronary syndromes. JACC. Cardiovascular interventions. 2009;2:65-72

Nitrogen and Water. The USGS Water Science School. Retrieved from 3.

Reyes de la Cruz J.L., Ruiz Chavarría G., Hernández Zapata S. (2012) Pressure Behavior and Evolution of the Bubbles Inside the Pipes of an Experimental Installation of Centrifugal Pump During the Occurrence of Cavitation. In: Klapp J., Cros A., Velasco Fuentes O., Stern C., Rodriguez Meza M. (eds) Experimental and Theoretical Advances in Fluid Dynamics. Environmental Science and Engineering. Springer, Berlin, Heidelberg

Science and Technology. Encyclopedia. Retrieved from technology/physics/physics/bernoullis-principle

Winston BM, PB S. Radial access for pci in children with obstructive coronary artery disease. VASCULAR DISEASE MANAGEMENT 2012:9(9):E159-E162.


  • There are currently no refbacks.