Cardiovascular disease (CVD) is often referred to several different diseases and disorders of the heart and blood vessels that constitute cardiovascular or heart disease. CVD is one of the leading causes of death worldwide. Atherosclerosis is the most common pathological process leading to CVD, a disease of medium to large arteries that majorly causes heart attacks and strokes. The pathogenesis of atherosclerosis lesion is a very complex process that is associated with thickening of the intima layer, weakening of underlying intima. Many components of the vascular, metabolic, and immune systems are involved in this process. These lesions have been presented even in teenagers and young adults and although not clinically signiﬁcant at this stage, these lesions possess the potential to develop into clinically relevant lesions later on in over decades of life. This article will give an overview relationship between atherosclerosis and cardiovascular disease.
José M. Ordovás and Caren E. Smith. Epigenetics and cardiovascular disease. Nature reviews. Cardiology, 7(9):510–519, Sep 2010. 20603647[pmid].
Thomas A. Gaziano. Cardiovascular disease in the developing world and its cost-effective management. Circulation, 112(23):3547–3553, 2005.
Véronique L. Roger, Alan S. Go, Donald M. Lloyd-Jones, Robert J. Adams, Jarett D. Berry, Todd M. Brown, Mercedes R. Carnethon, Shifan Dai, Giovanni de Simone, Earl S. Ford, and et al. Heart disease and stroke statistics—2011 update. Circulation, 123(4), Feb 2011.
H C Stary, A B Chandler, S Glagov, J R Guyton, W Insull, M E Rosenfeld, S A Schaffer, C J Schwartz, W D Wagner, and R W Wissler. A deﬁnition of initial, fatty streak, and intermediate lesions of atherosclerosis. a report from the committee on vascular lesions of the council on arteriosclerosis, American Heart Association. Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 14(5):840–856, 1994.
Kristina Skålén, Maria Gustafsson, Ellen Knutsen Rydberg, Lillemor Mattsson Hultén, Olov Wiklund, Thomas L. Innerarity, and Jan Borén. Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature, 417(6890):750– 754, Jun 2002.
Norbert Leitinger. Oxidized phospholipids as modulators of inﬂammation in atherosclerosis. Current Opinion in Lipidology, 14(5), 2003.
Yutaka Nakashima, Elaine W. Raines, Andrew S. Plump, Jan L. Breslow, and Russell Ross. Upregulation of vcam-1 and icam1 at atherosclerosis-prone sites on the endothelium in the apoe-deﬁcientmouse. Arteriosclerosis, Thrombosis, and Vascular Biology, 18(5):842–851, 1998.
Göran K. Hansson, Anna-Karin L. Robertson, and Cecilia Söderberg-Nauclér. Inﬂammation and atherosclerosis. Annual Review of Pathology: Mechanisms of Disease, 1(1):297–329, 2006. PMID: 18039117.
Einar Eriksson, Xinling Xie, Joachim Werr, Peter Thoren, and Lennart Lindbom. Importance of primary capture and lselectin–dependent secondary capture in leukocyte accumulationininﬂammationandatherosclerosisinvivo. The Journal of experimental medicine, 194:205–18, 07 2001.
J. D. Smith, E. Trogan, M. Ginsberg, C. Grigaux, J. Tian, and M. Miyata. Decreased atherosclerosis in mice deﬁcient in both macrophage colony-stimulating factor (op) and apolipoprotein e. Proceedings of the National Academy of Sciences, 92(18):8264–8268, Aug 1995.
Nageswara R. Madamanchi, Aleksandr Vendrov, and Marschall S. Runge. Oxidative stress and vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(1):29–38, 2005.
Elisabet Svenungsson,Iva Gunnarsson,Guo Fei,Ingrid Lundberg, Lars Klareskog, and Johan Frostegård. Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with up-regulation of the tumor necrosis factor α/tumor necrosis factor receptor system in systemic lupus erythematosus. Arthritis and rheumatism, 48:2533–40, 09 2003.
Gerd Assmann and Antonio Gotto. Hdl cholesterol and protective factors in atherosclerosis. Circulation, 109:III8–14, 07 2004.
BJARNE ØSTERUD and EIRIK BJØRKLID. Role of monocytes in atherogenesis. Physiological Reviews, 83(4):1069–1112, 2003. PMID: 14506301.
Alan Tall, Laurent Yvan-Charvet, Naoki Terasaka, Tamara Pagler, and Nan Wang. Hdl, abc transporters, and cholesterol efﬂux: Implications for the treatment of atherosclerosis. Cell metabolism, 7:365–75, 06 2008.
Amy Z. Fan. Metabolic syndrome and progression of atherosclerosis among middle-aged us adults. Journal of Atherosclerosis and Thrombosis, 13(1):46–54, 2006.
Arcangelo Iannuzzi, Mario De Michele, Salvatore Panico, Egidio Celentano, Rong Tang, M. Gene Bond, Lucia Sacchetti, Federica Zarrilli, Rocco Galasso, Michele Mercuri, and Paolo Rubba. Radical-trapping activity, blood pressure, and carotid enlargement in women. Hypertension, 41(2):289–296, 2003.
Matthias W. Lorenz, Hugh S. Markus, Michiel L. Bots, Maria Rosvall, and Matthias Sitzer. Prediction of clinical cardiovascular events with carotid intima-media thickness. Circulation, 115(4):459–467, 2007.
Pierluigi Costanzo, Pasquale Perrone-Filardi, Enrico Vassallo, Stefania Paolillo, Paolo Cesarano, GregorioBrevetti, and Massimo Chiariello. Does carotid intima-media thickness regression predict reduction of cardiovascular events?: A meta analysis of 41 randomized trials. Journal of the American College of Cardiology, 56(24):2006 – 2020, 2010.
Margherita Bernetti, Rosanna Abbate, Gabriele Cerini, Gianfranco Gensini, Loredana Poggesi, and Maria Boddi. Carotid and femoral intima-media thickness as an early atherosclerotic marker. advantages and limits. Giornale italiano di cardiologia (2006), 12:72–81, 01 2011.
Kenny Rodriguez-Macias, Lars Lind, and Tord Naessen. Thicker carotid intima layer and thinner media layer in subjects with cardiovascular diseases: An investigation using noninvasive high-frequency ultrasound. Atherosclerosis, 189:393– 400, 01 2007.
Edoardo Vicenzini, Maria Ricciardi, Francesco Puccinelli, Marta Altieri, Nicola Vanacore, Vittorio di piero, and Gian Lenzi. Common carotid artery intima-media thickness determinants in a population study. Journal of ultrasound in medicine : ofﬁcial journal of the American Institute of Ultrasound in Medicine, 26:427–32; quiz 434, 05 2007.
Marsha Eigenbrodt, Zoran Bursac, Richard Tracy, Jawahar Mehta, KathrynRose, and David Couper. B-mode ultrasound common carotid artery intima-media thickness and external diameter: Cross-sectional and longitudinal associations with carotid atherosclerosis in a large population sample. Cardiovascular ultrasound, 6:10, 02 2008.
PaoloRubba,SalvatorePanico,M.GeneBond,GiuseppeCovetti, Egidio Celentano, Arcangelo Iannuzzi, Rocco Galasso, M. Antonietta Belisario, Antonella Pastinese, Lucia Sacchetti, Mario Mancini, and Francesco Salvatore. Site-speciﬁc atherosclerotic plaques in the carotid arteries of middle-aged women from southern italy. Stroke, 32(9):1953–1959, 2001.
Joseph F. Polak, Sharina D. Person, Gina S. Wei, Ayleen Godreau, David R. Jacobs, Anita Harrington, Stephen Sidney, and Daniel H. O’Leary. Segment-speciﬁc associations of carotid intima-media thickness with cardiovascular risk factors. Stroke, 41(1):9–15, 2010.
P Prati, D Vanuzzo, M Casaroli, A Di Chiara, F De Biasi, GA Feruglio, and PJ Touboul. Prevalence and determinants of carotid atherosclerosis in a general population. Stroke, 23(12):1705—1711, December 1992.
Caroline E. Wright, Katie O’Donnell, Lena Brydon, Jane Wardle, and Andrew Steptoe. Family history of cardiovascular disease is associated with cardiovascular responses to stress in healthy young men and women. International Journal of Psychophysiology, 63(3):275–282, Mar 2007.
C Bonithon-Kopp, P Y Scarabin, A Taquet, P J Touboul, A Malmejac, and L Guize. Risk factors for early carotid atherosclerosis in middle-aged french women. Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 11(4):966–972, 1991.
D.C. Chan, G.F. Watts, P.H.R. Barrett, and V. Burke. Waist circumference, waist-to-hip ratio, and body mass index as predictors of adipose tissue compartments in men. QJM: An International Journal of Medicine, 96(6):441–447, 06 2003.
Sebastien Czernichow, Andre Kengne, Rachel Huxley, George Batty, Bastiaan Galan, Diederick Grobbee, Avinesh Pillai, Sophia Zoungas, Michel Marre, Mark Woodward, Bruce Neal, and John Chalmers. Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: A prospective cohort study from advance. European journal of cardiovascular prevention and rehabilitation : ofﬁcial journal of the European Society of Cardiology, Working Groups on Epidemiology Prevention and Cardiac Rehabilitation and Exercise Physiology, 18:312–9, 04 2011.