Inorganic phosphate (Pi) is transported across the plasma membrane by sodium-dependent phosphate transporters belonging to solute carrier families 34 (SLC34) and 20A (SLC20A). SLC34 has been well characterized and studied. Recently, the role of SLC20A in many pathological conditions is emerged. In this review, a brief overview of characteristics of this family will be provided.
Biber J, Hernando N, et al. Phosphate Transporters and Their Function.Annual Review of Physiology, Vol 75 2013;75:535-550.
Forster IC, Hernando N, et al. Phosphate transporters of the SLC20 and SLC34 families.Mol Aspects Med 2013;34:386-95.
Forster IC, Hernando N, et al. Phosphate transport kinetics and structure-function relationships of SLC34 and SLC20 proteins.Curr Top Membr 2012;70:313-56.
Miyamoto K, Haito-Sugino S, et al. Sodium-dependent phosphate cotransporters: lessons from gene knockout and mutation studies.J Pharm Sci 2011;100:3719-30.
Segawa H, Yamanaka S, et al. Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice.Am J Physiol Renal Physiol 2007;292:F769-79.
Moschen I, Setiawan I, et al. Effect of NaPi-mediated phosphate transport on intracellular pH.Pflugers Archiv-European Journal of Physiology 2001;441:802-806.
Li X, Yang HY, et al. Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification.Circ Res 2006;98:905-12.
Villa-Bellosta R, Levi M, et al. Vascular smooth muscle cell calcification and SLC20 inorganic phosphate transporters: effects of PDGF, TNF-alpha, and Pi.Pflugers Arch 2009;458:1151-61.
Villa-Bellosta R, Bogaert YE, et al. Characterization of phosphate transport in rat vascular smooth muscle cells - Implications for vascular calcification.Arteriosclerosis Thrombosis and Vascular Biology 2007;27:1030-1036.
Di Marco GS, Hausberg M, et al. Increased inorganic phosphate induces human endothelial cell apoptosis in vitro.American Journal of Physiology-Renal Physiology 2008;294:F1381-F1387.
Sekiguchi S, Suzuki A, et al. Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter.Am J Physiol Renal Physiol 2011;300:F848-56.
Takeda E, Taketani Y, et al. The regulation and function of phosphate in the human body.Biofactors 2004;21:345-355.
Werner A, Dehmelt L, et al. Na+-dependent phosphate cotransporters: the NaPi protein families.J Exp Biol 1998;201:3135-42.
Gonzalez-Parra E, Tunon J, et al. Phosphate: a stealthier killer than previously thought? Cardiovasc Pathol 2012;21:372-81.
Akiko Ohi EH, Otoya U, et al. Inorganic phosphate homeostasis in sodium-dependent phosphate cotransporter Npt2b+/− mice.Am J Physiol Renal Physiol 2011;301:F1105-F1113.
Miller DG ER, Miller AD. Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus.Proc. Natl. Acad. Sci. USA 1994;91:78-82.
O'Hara B JS, Klinger HP, Blair DG, Rubinson H, Dunn KJ, Sass P, Vitek SM, Robins T. Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus.Cell Growth Differ 1990;1:119-27.
Kavanaugh MP MD, Zhang W, et al. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc Natl Acad Sci U S A 1994;91:7071-5.
Olah Z LC, et al. The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter. J Biol Chem 1994;269:25426-31.
Ravera S, Murer H, et al. An Externally Accessible Linker Region in the Sodium-Coupled Phosphate Transporter PiT-1 (SLC20A1) is Important for Transport Function.Cellular Physiology and Biochemistry 2013;32:187-199.