Vol. 1 No. 3 (2016)

Dated: Nov. 2017

Leader: Mdm. Hoang-Yen T. Dang

Analyst: Man H. Pham

Time conducted the survey by TTU: July 25, 2017 – October 10, 2017

The survey includes 18 questions that are categorized into 6 objectives: purpose of higher education, contemporary trend in choosing Vietnamese university, contemporary trend in studying abroad, factors affecting students’ choice of university, perceptions of current education situation, expectations about an ideal education environment.

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Bài viết sử dụng   phương pháp  hồi quy tuyến tính để nghiên   cứu sự tác động của văn hóa tổ chức đến kết quả của Công  ty May 10 trên các phương diện: chất lượng và sự đổi mới các hoạt động  tổ chức  (như: sản phẩm  và quy trình làm việc).  Kết quả nghiên  cứu cho thấy, các biến thuộc  yếu tố Văn  hóa,  gồm:  Tính chất nhóm;  Tính chất kinh doanh; Tuân  thủ theo thứ bậc; Tính tối ưu có ảnh  hưởng tới chất lượng và sự đổi mới các sản phẩm,  cùng quy trình làm việc trong Công ty này.

 The  paper  approaches  linear  regression  method  to  study  the  impact  of  organizational culture on the performance of Garment 10 Company, in terms of quality and innovation of organizational activities (e.g. product and working process). The output identifies variables of culture affecting product’s quality and innovation, and working process in the company, which are Nature of group; Nature of business; Hierarchical compliance; Optimum

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Phát triển bền vững theo vùng lãnh thổ đang là xu hướng chủ đạo trong chiến lược phát triển quốc gia của Việt Nam trong thời gian gần đây. Một số nước trên thế giới đã thành công, đặc biệt là các nước trong khối Liên minh Châu Âu, trong đó có Cộng hòa Liên bang (CHLB) Đức. Bài viết đề cập kinh nghiệm thành công của CHLB Đức với những nội dung như: Một số lý thuyết về phát triển bền vững vùng, lãnh thổ; Kinh nghiệm thực hiện chính sách phát triển bền vững vùng, lãnh thổ thành công của CHLB Đức; Các khuyến nghị về chính sách phát triển bền vững theo vùng lãnh thổ tại Việt Nam.

Sustainable development of territories has been a major trend in Vietnam's national development strategy recently. Some countries in the world have been successful in sustainable development of territories, especially European Union countries such as the Federal Republic of Germany. In this article, the author discussed how Germany had successfully developed theories of sustainable development of territories, how it conducted policies on sustainable development of territories, and how these experiences could be applied to the case of Vietnam.

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MỞ ĐẦU:

Con người sống trong thiên nhiên, ngoài những ký sinh trùng(KST) chỉ gây bệnh cho người, còn những KST ký sinh ở những loài động vật khác và lan truyền KST của các động vật này sang người. Yếu tố chính góp phần vào  bệnh động vật ở người do sự gia tăng tiếp xúc giữa người và động vật, đặc biệt là động vật hoang dã. Nguyên nhân có thể do sự xâm lấn những hoạt động của con người vào vùng động vật hoang dã hay do sự di chuyển của động vật hoang dã vào những vùng hoạt động của con người do những xáo trộn về bản thân con người  hay do môi trường. Ngày nay, bệnh động vật có một tầm quan trọng đặc biệt do đây là những bệnh chưa được nhận biết trước đây hoặc độ dữ của bệnh gia tăng ở những cộng đồng khiếm khuyết miễn dịch.

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There have been many clinical designations for crossover second toe deformity, including plantar plate tears, hammertoe, metatarsalgia, predislocation syndrome and metatarsophalangeal joint (MPJ) instability. However, the crossover second toe is a common and high problematic case of foot and ankle. Mostly, the issue is associated with some form of progressive bone metabolic degenerative condition as deforming arthritis that ends with a multitude of forefoot deformities. Although multiple theories have been suggested, the true underlying cause of the deformity is multifactorial and only some of these factors have been scientifically analyzed and clarified. Thismakes the situation more problematic as the procedure requires to treat associated bone deformities, tendinopathies and neuropathies all at the same time in order to achieve a good outcome. Anatomically and pathologically this condition is a result of few condition such as the aging process, the gradual deprivation of bone structure consequently of metabolic disorders and a chronic inflammatory state as result of a prolonged increasing of medial pull of the flexor apparatus effects in rupture or attenuation of the lateral collateral ligaments of the second MPJ complex with valgus tendency exacerbating the underlying problem and inflammation. A second co-deforming force is the dorsal pull of the long and short extensor tendons without opposition from the plantar plate resulting in a hammertoe deformity with dorsal contracture or dislocation of the toe at the MPJ. Therefore it’s essential to consider soft tissue deformity together with osseous deformity in crossover second toes. Inevitably, those who treat the condition commonly note there is a long metatarsal associated with the deformity with presence of tear to the plantar soft tissue structures together with prolonged periods of high peak pressures during walk.
An adjunctive concern is due to hypermobility of the first ray linked with elevated pressures  from plantar to the second metatarsal head region. The direct pressure coupled with adductus of the hallux, which may cause dorsal displacement of the second toe, may be also be one of the basic causes of the crossover second toe.We reported a case of a 56-year-old woman presented to our formation with multiple joint osteo-arthritis with painful swelling on shoulders, bilateral knees, lower back, ankles with a visible bilateral cross over second toe condition. An MRI and X-ray were performed, and objectified a multiple osteoarthritis and grade 4 dual cross over second toe syndrome with deformity associated with hallux valgus, hallux rigidus, neuroma of the third intermetatarsal space with metatarsus sub-luxation. The patient received a treatment of autologous PB-SCs infusion during a period of 3 weeks, the results showed a complete recovery of cross over second toe condition on both left and right foot.

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MỞ ĐẦU
Ngày nay thầy thuốc phải đối mặt với loại nhiễm trùng gây ra bởi vi trùng
đa kháng thuốc. Thí dụ cụ thể trong y văn thế giới là Staphylococcus aureus90%
các trường hợp đã kháng với Penicillin. 50% các trườnghợp vi trùng Escherichia
colikháng với Amoxycillin.
Điều đáng ngại là số kháng sinh mới ngày càng ít dần: trong 20 năm qua số
thuốc kháng sinh do FDA phê duyệt giảm 50%. Số vi trùng đa kháng thuốc gia
tăng, nguy cơ khủng bố sinh học cũng đe dọa khiến cho việc dùng thuốc trị vi
trùng đa kháng thuốc lúc này có tính thời sự nhất.
 Về mặt thực hành có thể kể các vi trùng đáng ngại hiện nay gồm có:
 -MRSA (Methicillin Resistant Staphylococcus aureus),
 -VRE (Vancomycin Resistant Enterococcus),
 -Penicillin resistant Streptococcus pneumoniae
 -ESBL (Extended Spectrum Betalactamase) do Gram-negative Bacteria,
 -Acinetobacter Baumannii,
 -Pseudomonas aeruginosa.

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The paper examined how technology integration into teaching and learning in Technical
Communication course or a non-CALL course compared that with a CALL course. The finding was that
besides tools dedicated to CALL and non-CALL courses respectively, the applications of technological
tools in non-CALL and CALL environments shared the common characteristics. CALL as well as nonCALL practitioners were suggested experimenting available tools and considering the purpose of the
course and the learning tasks before technological tools can be utilized to its fullest potential in the
classroom.
Introduction
The use of technology in the classroom has increasingly been the subject of many studies in
recent years (Mohammed & Al-Karaki, 2008). That said, integrating technology and the Internet into the
classroom is becoming more of a focus because effective use of educational technologies has been
recognized as an integral part of providing high-quality education. Bax (2003) suggested using
computer-assisted language learning (CALL) as a normal component in the language classroom. Jarvis
(2004) noted, “Computers now form a significant aspect of academic study whatever the discipline” (p.
114). To effectively deliver the content knowledge of a course, teachers are expected to utilize some
sorts of technology to enhance students’ learning. Widely accepted, the integration of technology in the
classroom by different teachers within and across disciplines is different. For example, teachers of CALL
courses could use technology in the classroom differently from teachers of other courses, thereinafter
referred to as non-CALL courses. Alternatively, teachers in face-to-face classrooms might use technology
differently from those of non-conventional classrooms. According to Levy and Stockwell (2006),
applications and technologies used in language learning should not be necessarily the same to those used
in other courses in other disciplines, but integrating technology in the classroom to achieve the learning
3
goals and continuity of technology use was essential. Therefore, the question to answer is how
technology is integrated into teaching and learningin non-CALL environments rather than CALL
settings, and whether the technological integrationof the two environments completely differs from each
other, or there are some applications in common between the two. Therefore, the aim of the paper is
addressing the aforementioned idea that is worded into the following questions:
1. How is technology integrated into teaching andlearning in non-CALL environments?
2. What application does this have in CALL, if any?

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Hiện nay các bác sĩ điều trị có thể gặp phải thất bại điều trị các nhiễm khuẩn cộng đồng khi sử dụng các kháng sinh đầu tay được khuyến cáo trong các tài liệu kinh điển. Lý do của các thất bại điều trị này là vì các vi khuẩn gây nhiễm khuẩn cộng đồng hiện nay đã đề kháng với các kháng sinh đầu tay thông dụng. Minh họa cụ thể nhất là tình trạng đề kháng các kháng sinh như ampicillin, erythromycin, co-trimoxazol, và tetracycline của các tác nhân vi khuẩn chủ yếu nhất gây nhiễm khuẩn hô hấp cộng đồng. Đối với các nhiễm khuẩn phải nhập viện và nhiễm khuẩn bệnh viện thì các nhà điều trị cũng phải đối phó với tỷ lệ cao S. aureus kháng methicillin, trực khuẩn đường ruột tiết ESBL, P. aeruginosa đa kháng và A. baumannii kháng diện rộng. Chính vì các kiểu hình đề kháng này mà bác sĩ rất khó lựa chọn được một phát đồ kháng sinh điều trị hiệu quả cho các nhiễm khuẩn đang nằm viện hay mắc phải do nằm viện.  Để giúp các bác sĩ điều trị có thể chọn lựa kháng sinh đầu tay hiệu quả hay điều chỉnh được kháng sinh đầu tay, các phòng thí nghiệm lâm sàng tại các bệnh viện phải có khả năng phát hiện được một cách chính xác các đề kháng cần được quan tâm trên tác nhân vi khuẩn gây bệnh phân lập được từ bệnh nhân. Mục tiêu này đòi hỏi không chỉ phòng thí nghiệm phải tuân thủ các qui trình xét nghiệm kháng sinh đồ chuẩn (SOP) mà còn thường xuyên thực hiện nội kiểm để có thể phát hiệt được các sai sót trong quá trình xét nghiệm kháng sinh đồ. Ngoài ra, trước khi phúc trình kết quả đến lâm sàng, phòng xét nghiệm phải biết nhận dạng được các kết quả kháng sinh đồ bất thường để kiểm tra phát hiện được các sai sót hệ thống hay các bất thường thật sự mang ý nghĩa. Tham gia ngoại kiểm cũng rất cần thiết để phát hiện được các sai sót hệ thống.

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Abstract

Introduction: Vietnam is a tropical and agricultural country. Annually, there are 30,000 cases of snake bite. Two venomous snake families cause the big medical problem. In this, Calloselasma rhodostoma (CR) is the most dangerous snake. Therefore, since 2001, the scientific research collaborations between Vietnam (VN) and Uiversity of Southern California (USC) were established. Since 2014 this project has been approved by VN government. The aims of the 1st project are to establish the technological process for purification of disintegrin from CR venom of VN (CRd.VN), to determin the molecular weigh, structure and its biological antitumor activities. Methods: The process of collection, lyophilization of CR venom from VN. Protein concentration of CR venom was determined by BCA assay. High Performance Liquid Chromatography (HPLC), SDS-PAGE, Mass spectrometry (MS)analysis and sequencing by tryptic digestion were used for purification of CRd.VN and its molecular weight (MW) and structure. Standard cell biology methods were employed to characterize CRd’s abilities (in vitro) to inhibit platelet aggregation, adhesion, migration and invasion of tumor cells. Its anti-cancer activity in a breast cancer (BC) murine model (in vivo ) was tested.The resuls: Peak No:7 of HPLC (CRd.VN), showed a single ≈10 kDa band on SDS-PAGE gel. CRd.VN’s MW, structure and the sequence are 7.33 kDa, a monomer containing 68 amino acids with an RGD motif (position 49-51) and 6 disulfide bonds. The anti-cancer activities of CRd.VN are very strong. Conclusion: We have shown that CRd.VN is a possible anti-tumor agent with clinical potential. However, further research is required on CRd.VN recombinant production, preliminary pharmacokinetics/ toxicology properties and anti-tumor activities.
Keyword: CRd anti-cancer.

(1):Vietnam Institute on Toxicology (VST).
(2):University of Medicine & Pharmacy of Haiphong.
(3):Biochemistry and Molecular Biology, Keck School of Medicine of USC.

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ABSTRACT: Elevated plasma levels of inorganic phosphate (Pi) are harmful, causing, among other complications, vascular calcificationanddefective insulin secretion.Theunderlying molecularmechanismsof thesecomplications remain poorly understood.Wedemonstrated the role ofPi transport across theplasmalemmaonPi toxicity in INS-1Erat clonalb cells and rat pancreatic islet cells.Type III sodium–phosphate cotransporters (NaPi) are the predominant Pi transporters expressed in insulin-secreting cells. Transcript and protein levels of PiT-1 and -2, isotypes of type III NaPi, were upregulated by high Pi incubation. In patch-clamp experiments, extracellular Pi elicited a Na+-dependent, inwardly rectifying current, which was markedly reduced under acidic extracellular conditions. Cellular uptake of Pi elicited cytosolic alkalinization; intriguingly, this pH change facilitated Pi transport into the mitochondrial matrix. Increased mitochondrial Pi uptake accelerated superoxide generation, mitochondrial permeability transition, and endoplasmic reticulum stress-mediated translational attenuation, leading to reduced insulin content and impaired glucosestimulated insulin secretion. Silencing of PiT-1/-2 prevented Pi-induced superoxide generation andmPT, and restored insulin secretion. We propose that Pi transport across the plasma membrane and consequent cytosolic alkalinization could be a therapeutic target for protection from Pi toxicity in insulin-secreting cells, as well as in other cell types.—Nguyen, T. T., Quan, X., Xu, S.,Das, R., Cha, S.-K., Kong, I. D., Shong, M., Wollheim, C. B., Park,K.-S. Intracellular alkalinization by phosphate uptake via type III sodium–phosphate cotransporter participates in high phosphateinduced mitochondrial oxidative stress and defective insulin secretion. FASEB J. 30, 000–000 (2016). www.fasebj.org

 

KEY WORDS: inorganic phosphate • pancreatic b cells • mitochondrial permeability transition • endoplasmic reticulum stress • superoxide

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Critical problems in Vietnam — such as food safety, traffic management, saltwater
intrusion, and wastewater management — require novel Internet of Things (IoT)
solutions. Here, the authors analyze current research and developments and
propose specific IoT services as solutions.

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One of the most considered functions of MHC molecules is utilized to bind to peptide fragments originated from pathogens and display them on the cell surface for later recognition by the appropriate T-cells. The olfactory system also called sense of smell is the part of the sensory system used for smelling (olfaction). Many reports revealed that olfactory receptors (ORs) are encoded by the largest multigene family in mammals. Moreover, several researches suggested that the activation of ORs also have the links to reproductive and immune systems. Understanding the operation mechanism of OR system could lead to the understanding about the activation mechanisms of the immune system to later apply to improve the life quality as well as to develop some better strategies in the livestock industry. Although, the results from this report show the linkage which is not strong between Olfactory receptor clusters and Major Histocompatibility Complex region, they still have large number of OR genes located on the same chromosome with MHC regions, such as 77 and 253 OR genes on MHC chromosomes of cattle and porcine, respectively.

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Cái ghẻ Sarcoptes scabiei là loài mạt có kích thước rất nhỏ chỉ quan sát được dưới kính hiển vi. Có nhiều loài S. scabiei ký sinh ở nhiều loại ký chủ khác nhau: người, động vật hữu nhũ nuôi và hoang dã, khó phân biệt khi quan sát hình thể với kính hiển vi

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A diverticulum is a sac or pouch arising from a tubular organ, such as the esophagus. This review focuses on diverticula of the esophagus. In practice, the Zenker diverticulum, a type of diverticulum that arises from the posterior hypopharynx, is the most frequent.

Esophageal diverticula are classified by location in the esophagus. Upper (pharyngoesophageal, Killian-Jamieson, or Zenker), middle, or lower (epiphrenic). Besides anatomical location, several other ways to classify diverticula of the esophagus and hypopharynx exist. Congenital diverticula are diverticula that are present at birth, while acquired diverticula develop later in life. Diverticula of the esophageal body can sometimes be difficult to classify as congenital or acquired.^[1]

Diverticula also may be classified on the basis of histopathology. True diverticula contain all layers of the intestinal tract wall. False diverticula, also known as pseudodiverticula, occur when herniation of mucosa and submucosa through a defect in the muscular wall occurs (eg, Zenker diverticulum).

Finally, acquired diverticula of the esophagus and hypopharynx also may be classified according to their pathogenesis as pulsion diverticula or traction diverticula. Pulsion diverticula form as a result of high intraluminal pressures against weaknesses in the GI tract wall. Zenker diverticulum occurs due to increased pressure in the oropharynx during swallowing against a closed upper esophageal sphincter. An epiphrenic diverticulum occurs from increased pressure during esophageal propulsive contractions against a closed lower esophageal sphincter.^[2] In contrast, traction diverticula occur as a consequence of pulling forces on the outside of the esophagus from an adjacent inflammatory process (eg, involvement of inflamed mediastinal lymph nodes in tuberculosis or histoplasmosis).

Most esophageal diverticula occur in middle-aged adults and elderly people. Presentation in infants and children is rarely seen.

Zenker diverticula typically present in people older than 50 years and especially present during the seventh and eighth decades of life.

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Pulmonary embolism (PE) is a common and lethal condition causing mostly from thrombi in iliac and femeral veines. Most patients who succumb to pulmonary embolism do so within the first few hours of the event. Despite diagnostic advances, delays in pulmonary embolism diagnosis are common and represent an important issue (1) As a cause of sudden death, massive pulmonary embolism is second only to sudden cardiac death in US. In patients who survive a pulmonary embolism, recurrent embolism and death can be prevented with prompt diagnosis and therapy. Unfortunately, the diagnosis is often missed because patients with pulmonary embolism present with nonspecific signs and symptoms. If left untreated, approximately one third of patients who survive an initial pulmonary embolism die from a subsequent embolic episode. After 2 years suffered from PE, 3.8% of the patients develop chronic thromboembolic pulmonary arterial hypertension (CTEPH) (2).

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Blastocyst implantation requires the best communication between the mother’s uterus and a competent embryo. Even before the embryo enter the uterus, the endometrial tissue undergoes the process of decidualization to support the anchoring of the blastocyst and provides the blastocyst with nutrition until the fully functional placenta is formed. In this review, I summarize all the molecular and morphological events necessary for the decidualization in mice and human.

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