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The Review for Olfactory Receptor Genes

Truong Nguyen

Abstract

Mammals use the olfactory system as one of the basic instincts to avoid dangers and search for food. Many researches showed olfactory receptors (ORs) in mammals are encoded by the largest multigene family. Beside it has been suggested that the activation of ORs also have the links to reproductive and immune systems. Understanding the operation mechanism of OR system could lead to the way to improve the human’s life quality as well as to develop some better strategies in the livestock industry. Our report here revealed the almost complete data sets of the current OR genes from NCBI database. Although the number of functional OR genes in pigs (1,113) and cows (881) are lower than rats (1,201) and mice (1,037) as well, they are still relatively high and should be highly considered for further application in the livestock industry, especially in the process to produce the best and suitable food for them. The most important aspect is this data could contribute as the available data to get more understanding in the evolutionary process of species through the environment condition changed.

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References

Buck L, Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65: 175-187.

Buck LB (1996) Information coding in the vertebrate olfactory system. Annu Rev Neurosci 19: 517-544.

Touhara K (2002) Odor discrimination by G protein-coupled olfactory receptors. Microsc Res Tech 58: 135-141.

Firestein S (2001) How the olfactory system makes sense of scents. Nature 413: 211-218.

Mombaerts P (1999) Seven-transmembrane proteins as odorant and chemosensory receptors. Science 286: 707-711.

Glusman G, Yanai I, Rubin I, Lancet D (2001) The complete human olfactory subgenome. Genome Res 11: 685-702.

Niimura Y, Nei M (2003) Evolution of olfactory receptor genes in the human genome. Proc Natl Acad Sci U S A 100: 12235-12240.

Zozulya S, Echeverri F, Nguyen T (2001) The human olfactory receptor repertoire. Genome Biol 2: RESEARCH0018.

Malnic B, Godfrey PA, Buck LB (2004) The human olfactory receptor gene family. Proc Natl Acad Sci U S A 101: 2584-2589.

Lee K, Nguyen DT, Choi M, Cha SY, Kim JH, et al. (2013) Analysis of cattle olfactory subgenome: the first detail study on the characteristics of the complete olfactory receptor repertoire of a ruminant. BMC Genomics 14: 596.

Nguyen DT, Lee K, Choi H, Choi MK, Le MT, et al. (2012) The complete swine olfactory subgenome: expansion of the olfactory gene repertoire in the pig genome. BMC Genomics 13: 584.

Niimura Y, Nei M (2007) Extensive gains and losses of olfactory receptor genes in mammalian evolution. PLoS One 2: e708.

Olender T, Fuchs T, Linhart C, Shamir R, Adams M, et al. (2004) The canine olfactory subgenome. Genomics 83: 361-372.

Quignon P, Giraud M, Rimbault M, Lavigne P, Tacher S, et al. (2005) The dog and rat olfactory receptor repertoires. Genome Biol 6: R83.

Young JM, Friedman C, Williams EM, Ross JA, Tonnes-Priddy L, et al. (2002) Different evolutionary processes shaped the mouse and human olfactory receptor gene families. Hum Mol Genet 11: 535-546.

Zhang X, Firestein S (2002) The olfactory receptor gene superfamily of the mouse. Nat Neurosci 5: 124-133.

Zhang X, Rodriguez I, Mombaerts P, Firestein S (2004) Odorant and vomeronasal receptor genes in two mouse genome assemblies. Genomics 83: 802-811.

Godfrey PA, Malnic B, Buck LB (2004) The mouse olfactory receptor gene family. Proc Natl Acad Sci U S A 101: 2156-2161.

Niimura Y, Nei M (2005) Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods. Proc Natl Acad Sci U S A 102: 6039-6044.

Freitag J, Krieger J, Strotmann J, Breer H (1995) Two classes of olfactory receptors in Xenopus laevis. Neuron 15: 1383-1392.

Freitag J, Ludwig G, Andreini I, Rossler P, Breer H (1998) Olfactory receptors in aquatic and terrestrial vertebrates. J Comp Physiol A 183: 635-650.

Freitag J, Beck A, Ludwig G, von Buchholtz L, Breer H (1999) On the origin of the olfactory receptor family: receptor genes of the jawless fish (Lampetra fluviatilis). Gene 226: 165-174.

Ngai J, Dowling MM, Buck L, Axel R, Chess A (1993) The family of genes encoding odorant receptors in the channel catfish. Cell 72: 657-666.

Barth AL, Dugas JC, Ngai J (1997) Noncoordinate expression of odorant receptor genes tightly linked in the zebrafish genome. Neuron 19: 359-369.

Cao Y, Oh BC, Stryer L (1998) Cloning and localization of two multigene receptor families in goldfish olfactory epithelium. Proc Natl Acad Sci U S A 95: 11987-11992.

Dugas JC, Ngai J (2001) Analysis and characterization of an odorant receptor gene cluster in the zebrafish genome. Genomics 71: 53-65.

Sun H, Kondo R, Shima A, Naruse K, Hori H, et al. (1999) Evolutionary analysis of putative olfactory receptor genes of medaka fish, Oryzias latipes. Gene 231: 137-145.

Kondo R, Kaneko S, Sun H, Sakaizumi M, Chigusa SI (2002) Diversification of olfactory receptor genes in the Japanese medaka fish, Oryzias latipes. Gene 282: 113-120.

Alioto TS, Ngai J (2005) The odorant receptor repertoire of teleost fish. BMC Genomics 6: 173.

Chess A, Simon I, Cedar H, Axel R (1994) Allelic inactivation regulates olfactory receptor gene expression. Cell 78: 823-834.

Niimura Y, Nei M (2006) Evolutionary dynamics of olfactory and other chemosensory receptor genes in vertebrates. J Hum Genet 51: 505-517.

Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, et al. (1998) Distribution of olfactory receptor genes in the human genome. Nat Genet 18: 243-250.

Jahromi MM (2012) Haplotype specific alteration of diabetes MHC risk by olfactory receptor gene polymorphism. Autoimmun Rev 12: 270-274.

Solovieff N, Milton JN, Hartley SW, Sherva R, Sebastiani P, et al. (2010) Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. Blood 115: 1815-1822.

Dorries KM, Adkins-Regan E, Halpern BP (1997) Sensitivity and behavioral responses to the pheromone androstenone are not mediated by the vomeronasal organ in domestic pigs. Brain Behav Evol 49: 53-62.

Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, et al. (2003) Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 299: 2054-2058.

Wetzel CH, Oles M, Wellerdieck C, Kuczkowiak M, Gisselmann G, et al. (1999) Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes. J Neurosci 19: 7426-7433.

Zhao H, Ivic L, Otaki JM, Hashimoto M, Mikoshiba K, et al. (1998) Functional expression of a mammalian odorant receptor. Science 279: 237-242.

Krautwurst D, Yau KW, Reed RR (1998) Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell 95: 917-926.

Malnic B, Hirono J, Sato T, Buck LB (1999) Combinatorial receptor codes for odors. Cell 96: 713-723.

Kajiya K, Inaki K, Tanaka M, Haga T, Kataoka H, et al. (2001) Molecular bases of odor discrimination: Reconstitution of olfactory receptors that recognize overlapping sets of odorants. J Neurosci 21: 6018-6025.

Touhara K, Sengoku S, Inaki K, Tsuboi A, Hirono J, et al. (1999) Functional identification and reconstitution of an odorant receptor in single olfactory neurons. Proc Natl Acad Sci U S A 96: 4040-4045.

Gaillard I, Rouquier S, Pin JP, Mollard P, Richard S,

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