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The Linkage Between Olfactory Receptor Genes and Major Histocompatibility Complex

Truong Nguyen

Abstract

One of the most considered functions of MHC molecules is utilized to bind to peptide fragments originated from pathogens and display them on the cell surface for later recognition by the appropriate T-cells. The olfactory system also called sense of smell is the part of the sensory system used for smelling (olfaction). Many reports revealed that olfactory receptors (ORs) are encoded by the largest multigene family in mammals. Moreover, several researches suggested that the activation of ORs also have the links to reproductive and immune systems. Understanding the operation mechanism of OR system could lead to the understanding about the activation mechanisms of the immune system to later apply to improve the life quality as well as to develop some better strategies in the livestock industry. Although, the results from this report show the linkage which is not strong between Olfactory receptor clusters and Major Histocompatibility Complex region, they still have large number of OR genes located on the same chromosome with MHC regions, such as 77 and 253 OR genes on MHC chromosomes of cattle and porcine, respectively.

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One of the most considered functions of MHC molecules is utilized to bind to peptide fragments originated from pathogens and display them on the cell surface for later recognition by the appropriate T-cells. The olfactory system also called sense of smell is the part of the sensory system used for smelling (olfaction). Many reports revealed that olfactory receptors (ORs) are encoded by the largest multigene family in mammals. Moreover, several researches suggested that the activation of ORs also have the links to reproductive and immune systems. Understanding the operation mechanism of OR system could lead to the understanding about the activation mechanisms of the immune system to later apply to improve the life quality as well as to develop some better strategies in the livestock industry. Although, the results from this report show the linkage which is not strong between Olfactory receptor clusters and Major Histocompatibility Complex region, they still have large number of OR genes located on the same chromosome with MHC regions, such as 77 and 253 OR genes on MHC chromosomes of cattle and porcine, respectively.

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